Throughout Latin America has there ever been a mistrust of the indigenous against the spanish-speaking?

I don't know if that question is clear, but I would like to find out if there has ever been, or is, a form of the indigenous of latin america (in any country, but particularly of the main areas of spanish colonisation/slavery - peru, mexico etc) not trusting the spanish=speaking population... I mean in terms of language? did this cause the spanish spoken in latin america to change? adopt local words? - there probably isn't, but I was just thinking :p