High instances throughout world history of women iconic for pioneering their field abandoning women as whole?

Other than by being born female by chance rather than choice, objectively how much did many women like Queen Elizabeth, Catherine the Great or Cleopatra, synonymous with being symbols of power, liberation and progress for other women, actively do to fight the injustices that women in general faced within their societies? How many female heads of state outside of recent history can be attributed with significant if any social reforms in that regard?